Modeling Severe Acute Respiratory Syndrome Coronavirus 2019 (SARS-CoV-19) Incidence across Conterminous US Counties: A Spatial Perspective

Coronavirus in severe acute respiratory syndrome (SARS).

In November 2002, an outbreak of a life-threatening ‘atypical pneumonia’ for which no etiological agent could be identified occurred in Guangdong Province, China. In March 2003, a similar outbreak was reported in Hong Kong [1]. Cases of similar respiratory illness were subsequently reported globally including China, Taiwan, Singapore, Vietnam, Canada and USA. This syndrome is a new clinical ent...

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

The coronavirus SARS-CoV is the primary cause of the life-threatening severe acute respiratory syndrome (SARS). With the aim of developing therapeutic agents, we have tested peptides derived from the membrane-proximal (HR2) and membrane-distal (HR1) heptad repeat region of the spike protein as inhibitors of SARS-CoV infection of Vero cells. It appeared that HR2 peptides, but not HR1 peptides, w...

(SARS-CoV) Pulmonary Infection of Mice Acute Respiratory Syndrome-Coronavirus Mechanisms of Host Defense following Severe

Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV.

Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment laboratories at biosafety level 3 (BSL3). The virus was inactivated by ultraviolet light (UV) at 254 nm, heat tr...

Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry.

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health. Here we describe conditions that result not only in the efficient expression of the SARS-CoV spike (S) protein on the surface of cells, but in its incorporation into lentiviral particles that can be used to transduce cells in an S glycoprote...